Refugee Receptors Switch Sides
Human heart muscle cells (cardiomyocytes) express two different types of ╬▓ adrenergic receptor: ╬▓1AR and ╬▓2AR. Both respond to the same hormones and couple to the same biochemical signaling effectors, yet they elicit different cellular responses. This article reviews the work of Nikolaev et al. which shows that failing cardiomyocytes exhibit membrane remodeling that disrupts compartmentalization of ╬▓ARs. This may be a primary mechanism for the pathological effects of ╬▓AR signaling in heart failure and disease.