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Cell Signaling: To Divide or Not to Divide

Access to the article is free, however registration and sign-in are required. How a cell integrates multiple signals into an all-or-none decision is the fascinating subject of a new study by Justman et al. (1) on the maturation of amphibian oocytes in response to the hormone progesterone. On page 509 of this issue, the authors show that interacting feedback loops within the network of cellular signaling pathways modulate sensitivity to progesterone in response to external cues.

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