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Science Signaling Podcast: 19 February 2013

This Podcast features an interview with Jayne Danska, senior author of a paper that was released on Science Express on 17 January 2013. A group led by Danska has uncovered an interaction between the gut microbiota and sex hormones that influences the development of type 1 diabetes in mice. Although type 1 diabetes shows no sex bias in humans, females of the non-obese diabetic (NOD) mouse strain are about twice as likely to develop the disease as are NOD males. Markle et al. report that male-type gut microbiota were associated with an increase in testosterone that reduces an individual's chances of developing type 1 diabetes. This protection was prevented by interfering with testosterone signaling.

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