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Endothelin Action on Pituitary Lactotrophs: One Receptor, Many GTP-Binding Proteins

The endothelins are a family of hormones that have a biphasic action on pituitary lactotrophs. The initial effect is stimulatory, followed later by inhibition that persists long after the agonist has been removed. Recent research has uncovered several G protein pathways that mediate these effects.

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