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Insulin Vesicle Release: Walk, Kiss, Pause ... Then Run

In this review, we discuss the molecular mechanisms involved in vesicle trafficking within the pancreatic ß-cell and the mechanisms whereby these may be regulated. We then go on to describe recent evidence that suggests that vesicle fusion at the plasma membrane is a partly reversible process ("kiss and run" or "cavity recapture"). We propose that vesicles may participate in a exo-endocytotic cycle in which a proportion of those that have already undergone an interaction with the plasma membrane may exchange exocytotic machinery with maturing vesicles.

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