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Akt Demoted in Glioblastoma

In glioblastomas, an Akt-independent, PTEN (phosphatase and tensin homolog deleted on chromosome ten)–regulated signaling pathway links EGFR (epidermal growth factor receptor) to the phosphorylation of TOR (target of rapamycin) and of the ribosomal protein S6 and to the control of cell replication. Although PKCα (protein kinase Cα) has been identified as an essential component, the detailed wiring of this previously unexplored noncanonical pathway remains to be worked out.

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Classifications


Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Peter K. Vogt of Department of Molecular and Experimental Medicine, The Scripps Research Institute, Jonathan R. Hart of Department of Molecular and Experimental Medicine, The Scripps Research Institute
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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Collection:
STKE/Science Signaling


     
   

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