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A Kelch {beta} Propeller Featuring as a G{beta} Structural Mimic: Reinventing the Wheel?

New genetic and protein interaction data suggest that G protein α subunits may have partners with primary sequences that are quite divergent. How this is achieved may be through the adoption of similar structures, the β propeller, by both proteins containing WD-40 repeats and kelch domains. Gettemans et al. describe results in yeast that suggest that kelch-domain proteins may serve as previously unrecognized β subunits in the heterotrimeric G protein complex.

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Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Jan Gettemans of Department of Biochemistry, Rommelaere Institute, Kris Meerschaert of Faculty of Medicine and Health Sciences, Rommelaere Institute, Joel Vandekerckhove of Flanders Interuniversity Institute for Biotechnology (VIB), Rommelaere Institute, Veerle De Corte of Ghent University, Rommelaere Institute
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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