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Coupling Gating with Ion Permeation in ClC Channels

In ClC chloride (Cl) channels, unlike cation-selective ion channels, ion permeation is intimately coupled to fast gating. Recent research comparing the crystallographic structure of a bacterial ClC channel with functional studies of a Torpedo ClC channel suggests that gating depends on the negatively charged carboxyl group on a glutamate residue, which blocks the channel pore. In this model, the permeating Cl competes with the carboxyl group for an anion-binding site in the channel pore. This model of Cl competition with a glutamate gate helps explain the effect of intracellular Cl on channel gating; the mechanism underlying the effects of extracellular Cl, however, remains to be determined, as does the nature of the Cl channel slow gate.

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Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Tsung-Yu Chen of Center for Neuroscience and Department of Neurology, University of California
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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