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Cellular Distribution of Bcl-2 Family Proteins

Proteins synthesized in the cytosol can be inserted into or across organellar membranes depending on the signals present in their primary sequences. Proteins of the Bcl-2 family, which includes proteins that promote programmed cell death (apoptosis) and proteins that inhibit apoptosis, have signals that can target particular members to either the mitochondria or the endoplasmic reticulum (ER) or both. Germain and Shore discuss evidence for a role for the anti-apoptotic members of the family at the ER and describe an interaction with the FK506 binding protein, FKBP38, that may regulate the relative distribution of Bcl-2 proteins at the ER or mitochondria. This interaction may control the cell's sensitivity to apoptotic stimuli.

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Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Marc Germain of Department of Biochemistry, Quebec, Gordon C. Shore of McGill University, Quebec
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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