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Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias?

Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassim channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.

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Classifications


Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Harry A. Fozzard of Departments of Medicine and of Neurobiology Pharmacology and Physiology and Cardiac Electrophysiology Laboratories, University of Chicago, John W. Kyle of Departments of Medicine and of Neurobiology Pharmacology and Physiology and Cardiac Electrophysiology Laboratories, University of Chicago
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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