HomeAbout

SIGN IN   Advanced Search










 
Browse Illustration
CTLA-4 Negative Signaling via Lipid Rafts: A New Perspective

Proper function of the immune system requires that activation of T cells is precisely regulated. Responses to the T cell receptor are modulated by signals from other receptors. CTLA-4 (cytotoxic T lymphocyte antigen-4, also called CD152), for example, inhibits cytokine production and proliferation of T cells. Activation of T cells is associated with the accumulation of signaling proteins in lipd rafts--microdomains of the plasma membrane enriched in cholesterol and glycosphingolipds. Rudd et al. discuss evidence that CTLA-4 might inhibit cytokine production and T cell proliferation by limiting the assembly of lipid rafts, which are critical to the formation of a functional immunological synapse between antigen-presenting cells and T cells.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.


Subscribe and
View Resource

Classifications


Resource Type: Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Christopher E. Rudd of Department of Haematology, Imperial College School of Science Technology and Medicine at Hammersmith Hospital, Margarita Martin of Department of Haematology, Imperial College School of Science Technology and Medicine at Hammersmith Hospital, Helga Schneider of Department of Haematology, Imperial College School of Science Technology and Medicine at Hammersmith Hospital
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

Comments


» Sign In or register to post comments.


Collection:
STKE/Science Signaling


     
   

SITE MAP | CONTACT | POLICIES

Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.