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Heterogeneous Cardiac Proteasomes: Mandated by Diverse Substrates?- Figure 1

This figure illustrates how cardiac proteasomes are dynamic and heterogeneous organelles mandated by a diverse substrate repertoire Proteasomes are essential nodes of cardiomyocyte signaling. The functional dynamics of cardiac proteasomes are highly regulated via multifaceted mechanisms. The molecular heterogeneity of proteasome complexes as the basis of their functional diversity manifests as differences in subcellular location, incorporation of inducible subunits, assembly with unique regulatory particles, and posttranslational modifications. There is a growing body of evidence to suggest that the diverse array of regulatory particles complexing to 20S core particles specializes proteasomes to degrade specific substrate repertoires. Thus proteasome heterogeneity fulfills the demand for degradation of diverse substrate repertoires in discrete functional locations within cardiomyocytes.

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Resource Type: Digital Presentation (Powerpoint), Illustration, Image, Journal Article/Issue
Audience Level: Undergraduate lower division (Grades 13-14), Undergraduate upper division (Grades 15-16), Graduate, Professional (degree program), General Public, Informal Education, Continuing Education

Author and Copyright

Authors and Editors: Sarah B Scruggs of David Geffen School of Medicine at UCLA Departments of Physiology and Medicine, Peipei Ping of Division of Cardiology, Chenggong Zong of David Geffen School of Medicine at UCLA Departments of Physiology and Medicine
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