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The Bcl-2 Protein Family: Arbiters of Cell Survival

Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens. Those most similar to Bcl-2 promote cell survival by inhibiting adapters needed for activation of the proteases (caspases) that dismantle the cell. More distant relatives instead promote apoptosis, apparently through mechanisms that include displacing the adapters from the pro-survival proteins. Bcl-2 family members are essential for maintenance of major organ systems, and mutations affecting them are implicated in cancer.

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Resource Type: Journal article/Issue, Review, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Jerry Adams of Walter and Eliza Hall Institute of Medical Research, Suzanne Cory of Walter and Eliza Hall Institute of Medical Research
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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American Association for the Advancement of Science


     
   

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