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TGF-{beta} Superfamily Signaling and Left-Right Asymmetry

The invariant left-right asymmetry of visceral organs in higher chordates depends on signal transduction initiated by the transforming growth factor-β (TGF-β) superfamily of secreted proteins during early embryogenesis. TGF-β proteins are well known for their roles in numerous other developmental processes, including the specification of dorsoventral pattern. This review discusses current knowledge of the regulatory hierarchies that ensure invariant left-right asymmetry as well as the potential mechanisms that permit a common set of signaling proteins to specify pattern along both the left-right and dorsoventral body axes.

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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Malcolm Whitman of Department of Cell Biology, Harvard Medical School, Mark Mercola of Department of Cell Biology, Harvard Medical School
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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