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The Spark of Life: Electricity and Regeneration

A recent paper shows that a proton pump, the vacuolar-type adenosine triphosphatase (V-ATPase), is necessary for Xenopus tadpole tail regeneration. The V-ATPase is synthesized in distal cells of the regeneration bud as an early response to amputation, and its role in regeneration is specifically to pump H+ out of cells. Although the downstream effects of proton movement are not known, they may be mediated through changes in membrane potential. This work could reopen a consideration of the role of electric fields in regeneration, an issue that has caused much controversy in the past.

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Resource Type: Bibliography, Diagram, Illustration, Image, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Jonathan M. W. Slack of Stem Cell Institute, McGuire Translational Research Facility
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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