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Estrogen Actions in the Brain

Understanding of the mechanisms of estrogen action in the brain has always been poor. Neurons in several brain regions do not harbor estrogen receptor α (ERα) and yet are estrogen responsive. It was formerly thought that these responses represented indirect actions of estrogen. It is now evident that these neurons express ERβ and that estrogen receptors have diverse actions in the central nervous system. By clear delineation of the cellular expression and function of the two estrogen receptors, it is likely that, in the future, selective ERα and ERβ ligands will be developed and used for treatment of depression and behavioral disorders and may be useful in preventing degenerative diseases, such as Alzheimer's and Parkinson's disease.

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Resource Type: Bibliography, Diagram, Illustration, Image, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Ling Wang of Department of Medical Nutrition, Karolinska Institute, Sandra Andersson of Department of Medical Nutrition, Karolinska Institute, Margaret Warner of Department of Biosciences, Karolinska Institute, Jan-Ake Gustafsson of Department of Medical Nutrition, Karolinska Institute
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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