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Tangled Webs: Evidence of Cross-Talk Between c-Raf-1 and Akt

The apparent cross-communication that can occur between different cell signaling pathways indicates that some signaling mechanisms may be more complex than originally envisaged. Jun et al. discuss recent studies suggesting that two signaling pathways that can be activated by the same growth factor receptor, the Ras-Raf pathway and the phosphatidylinositol 3-kinase (PI3K)–Akt (protein kinase B) pathway, can integrate with each other to generate a particular response, depending on the cell type and the stage of cell differentiation.

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Classifications


Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Toni Jun of Dana Farber Cancer Institute and Harvard Medical School, Boston, Ole Gjoerup of Dana Farber Cancer Institute and Harvard Medical School, Boston, Thomas M. Roberts of Dana Farber Cancer Institute and Harvard Medical School, Boston
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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