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Neuro2A Differentiation by G{alpha}i/o Pathway

Signaling from Gi/o-coupled G protein–coupled receptors (GPCRs), such as the serotonin 1B, cannabinoid 1, and dopamine D2 receptors, inhibits cAMP production by adenylyl cyclases and activates protein kinases, such as Src, mitogen-activated protein kinases 1 and 2, and Akt. Activation of these protein kinases results in stimulation of neurite outgrowth in the central nervous system (CNS) and in neuronal cell lines. This Connections Map traces downstream signaling pathways from Gi/o-coupled GPCRs to key protein kinases and key transcription factors involved in neuronal differentiation. Components in the Science Signaling Connections Map are linked to Nature Molecule Pages. This interoperability provides ready access to detail that includes information about specific states for the nodes.

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Resource Type: Bibliography, Dataset, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Avi Ma'ayan of Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Sherry L. Jenkins of Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Alexander Barash of Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Ravi Iyengar of Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, image/svg+xml, text/html
Copyright and other restrictions: Yes
Cost: No

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