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Interleukin-1{beta} (IL-1{beta}) Processing Pathway

The innate immune system senses molecular patterns from invading microorganisms. Once activated, it orchestrates the inflammatory response by secreting proinflammatory cytokines, such as interleukin-1 (IL-1)–type cytokines, in particular IL-1β. IL-1 mediates the expression of a vast array of genes involved in secondary inflammation. IL-1–responsive genes coordinate all aspects of local inflammation and also attract and activate cells of the adaptive immune system at sites of infection. Moreover, the innate immune system can also sense a wide range of nonmicrobial molecular patterns that represent danger or damage signals. These signals activate the NALP3-inflammasome pathway, which plays a central role in acute and chronic sterile inflammation. Here, we describe the essential components of the NALP3-inflammasome that control processing and release of IL-1β.

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Resource Type: Bibliography, Dataset, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Axel Weber of Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University Giessen, Peter Wasiliew of Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University Giessen, Michael Kracht of Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University Giessen
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, image/svg+xml, text/html
Copyright and other restrictions: Yes
Cost: No


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