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Signaling Mechanisms in Mammalian Myoblast Fusion

Skeletal muscles are formed by the fusion of multiple myoblasts during development. Myoblast fusion is also essential for the growth and repair of injured myofibers. Recent investigations have shown that the process of myoblast fusion involves the activation of several cell signaling pathways, including those mediated by nuclear factor κB, mitogen-activated protein kinases, Wnt, calcineurin–nuclear factor of activated T cells c2, transforming growth factor–β–Smad4, and the Rho guanosine triphosphatases. In this Review, which contains 2 figures and 84 references, we summarize the mechanisms by which the activation of these signaling pathways stimulates myoblast fusion.

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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Ashok Kumar of School of Medicine, University of Louisville, Sajedah M. Hindi of School of Medicine, University of Louisville, Marjan M. Tajrishi of School of Medicine, University of Louisville
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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