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A Role for Hipk in the Hippo Pathway

Since characterization of the Hippo pathway as a major regulator of growth control and organ size, major efforts to unravel the molecular mechanisms that regulate this pathway have been undertaken. These investigations have led to the discovery of diverse upstream regulators of Hippo signaling, the majority of which function to activate the Hippo kinase cascade and thereby restrict the transcriptional output of the downstream targets, Yorkie (Yki) in flies and TAZ and YAP in mammals, collectively Yki/TAZ/YAP. Two studies have delineated a role for HIPK (homeodomain-interacting protein kinase) in promoting Yki/TAZ/YAP transcriptional activity.

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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Emad Heidary Arash of Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Liliana Attisano of Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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Collection:
STKE/Science Signaling


     
   

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