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GABA May Act as a Self-Limiting Trophic Factor at Developing Synapses

Early in development, synapses with glycine or γ-aminobutyric acid (GABA)-gated chloride channels exhibit the ability to depolarize postsynaptic cells. As the synapses mature and the gradient of chloride ions across the cell membrane is altered, these neurotransmitters signal an inhibitory response, hyperpolarizing the membrane and decreasing neuronal excitability. Kriegstein and Owens discuss how GABA-stimulated up-regulation of the expression of the potassium chloride cotransporter KCC2 may be the mechanism underlying this synaptic switch.

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Classifications


Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Arnold R. Kriegstein of Department of Neurology and Department of Pathology and at the Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons, David F. Owens of Department of Neurology and Department of Pathology and at the Center for Neurobiology and Behavior, Columbia College of Physicians and Surgeons
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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Collection:
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