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Is Dimerization Of Chemokine Receptors Functionally Relevant?

Chemokines activate lymphocytes by initiating signaling cascades through cell surface receptors that couple to heterotrimeric GTP-binding proteins. Thelen and Bagglioni describe why the recent proposal that these receptors form heterodimers and activate the Jak kinases for transducing signals should be viewed with caution.

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Resource Type: Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Marcus Thelen of Institute for Research in Biomedicine, Marco Baggiolini of Institute for Research in Biomedicine
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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