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A Call to Arms: The Cytokine Selection Service

The process by which nai¨ve T helper (TH) cells differentiate into the TH1 and TH2 subtypes has been well studied. However, there remain some unresolved issues pertaining to the requirements for the initial step of TH cell differentiation. Much debate exists about whether the roles of cytokines include the forcing of the initial steps of differentiation on nai¨ve TH cells, termed "instruction," or whether cytokines act in a supportive role, termed "selection," whereby newly differentiating TH cells are given the proper signals for survival and proliferation. A recent paper by Mullen et al., which helps delineate the role of cytokines in TH1 cell development, is addressed by Nelson; it appears that cytokines act in the selection stage of TH cell maturation.

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Classifications


Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: John W. Nelson of Science's Signal Transduction Knowledge Environment, American Association for the Advancement of Science
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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STKE/Science Signaling


     
   

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