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Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy

This STKE Review with two figures and 133 references discusses the signaling pathways that are implicated in both building muscle and losing muscle. Protein degradation pathways are activated in response to lack of muscle use, which leads to muscle atrophy. Muscle hypertrophy in response to exercise involves both changes in gene expression and protein activities in the existing myofibers and recruitment of satellite cells to increase myofiber numbers. Studies aimed at understanding the mechanisms underlying either muscular atrophy or hypertrophy have begun to identify the physiological determinants and clarify the molecular pathways responsible for the maintenance of muscle mass.

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Classifications


Resource Type: Diagram, Illustration, Image, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Vittorio Sartorelli of Muscle Gene Expression Group Laboratory of Muscle Biology, National Institute of Arthritis Musculoskeletal and Skin Diseases, Marcella Fulco of Muscle Gene Expression Group Laboratory of Muscle Biology, National Institute of Arthritis Musculoskeletal and Skin Diseases
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes

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Collection:
STKE/Science Signaling


     
   

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