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Human Papillomaviruses and Cell Signaling

Human papillomaviruses cause cancer of the stratified epithelium, and the incidence of infection with these viruses in the genital tract is high. The alterations in the biology of normal epithelial cells that lead to malignancy are a consequence of the activity of certain viral proteins, whose function is to create an environment conducive to the replication of the viral genome through inhibition of epithelial cell differentiation and stimulation of proliferation.

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Resource Type: Illustration, Image, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Dennis J. McCance of Department of Microbiology and Immunology and the James P. Wilmot Cancer Center, University of Rochester
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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