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Interleukin-4 (IL-4) Pathway

Interleukin-4 (IL-4) is a cytokine produced by TH2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma. Studies with long-term cell lines and primary cells have revealed differences in the signaling between these two experimental systems. Understanding these differences is important because therapeutic strategies targeting IL-4 and its signaling pathways are currently being tested to treat allergy and asthma.

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Resource Type: Bibliography, Dataset, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Ann Kelly-Welch of Program in Oncology at Marlene and Department of Microbiology and Immunology, University of Maryland and Stewart Greenebaum Cancer Center, Erica M. Hanson of Department of Biology, University of Maryland Baltimore County, Achsah D. Keegan of Program in Oncology at Marlene and Department of Microbiology and Immunology, University of Maryland and Stewart Greenebaum Cancer Center
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, image/svg+xml, text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
STKE/Science Signaling


     
   

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