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CELL BIOLOGY: A Pit Stop at the ER

Access to the article is free, however registration and sign-in are required. Although ligand activation of receptor signaling is well understood, less is known about how a cell switches off signaling by the activated receptor. In his Perspective, Gill discusses new work (Haj et al.) that visualizes one step in the process of deactivating a ligand-activated receptor tyrosine kinase--the dephosphorylation of the internalized receptor by a phosphatase in the endoplasmic reticulum.

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Resource Type: Journal article/Issue, Review, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Gordon N. Gill of University of California
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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