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CELL BIOLOGY: A Universal Bicarbonate Sensor

Access to the article is free, however registration and sign-in are required. The three principal molecular events that prepare sperm for fertilization are all controlled by the intracellular nucleotide adenosine 3',5'-monophosphate (cAMP). One of these, capacitation, is also regulated by bicarbonate ions. The elusive connection between cAMP and bicarbonate ions now appears to be solved as Kaupp and Weyand explain in their Perspective. Bicarbonate ions enter sperm through the anion transporter in the sperm plasma membrane and activate the soluble form of adenylyl cyclase, the enzyme that synthesizes cAMP (Chen et al.)

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Resource Type: Journal article/Issue, Review, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: U. Benjamin Kaupp of Institut für Biologische Informationsverarbeitung, Ingo Weyand of Institut für Biologische Informationsverarbeitung
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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