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VIROLOGY: CMV Makes a Timely Exit

Access to the article is free, however registration and sign-in are required. DNA viruses must first replicate their genome in the nucleus of the host cell before forming subviral particles that cross into the cytoplasm for the final stages of virion maturation. However, the nuclear envelope provides a physical barrier to the movement of subviral particles into the cytoplasm. In their Perspective, Sanchez and Spector discuss new work (Muranyi et al.) that reveals how cytomegalovirus recruits a host cell protein kinase C to modify the nuclear lamin meshwork of the nuclear envelope, thus enabling subviral particles to exit the nucleus.

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Resource Type: Diagram, Journal article/Issue, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Veronica Sanchez of Molecular Biology Section and Center for Molecular Genetics, University of California, Deborah H. Spector of Molecular Biology Section and Center for Molecular Genetics, University of California
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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