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DNA Damage and Tumor Surveillance: One Trigger for Two Pathways

Biological evolution ensures that several backup mechanisms always exist to prevent the failure of cellular processes of critical importance for life. This notion applies to processes aimed at preventing cancer development. Recent research suggests that the DNA damage response, activated in one of the earliest cellular responses to transformation, may elicit two independent tumor surveillance mechanisms. The first, and most well known, is activation of the proapoptotic molecule p53 and subsequent cellular suicide. The second, reported in a recent study, is induction of the expression of ligands for the activating immune receptor NKG2D. That DNA damage induces two independent tumor surveillance responses demonstrates how one tumor surveillance mechanism may be assisted by another to secure efficient protection against early tumorigenesis. The results also support the immunosurveillance theory of cancer and suggest that it may operate at very early stages of tumorigenesis.

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Resource Type: Bibliography, Diagram, Illustration, Journal article/Issue, Review
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Petter Hoglund of Microbiology and Tumor Biology Center, Karolinska Institutet Stockholm Sweden
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html
Copyright and other restrictions: Yes
Cost: Yes


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