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Part 1: Mechanisms of DNA Repair

The most deleterious form of DNA damage is a double-strand break (DSB), which can arise from errors in DNA replication, from the failure of topoisomerases to complete their cycles of DNA cutting and rejoining, from mechanical stress and from the action of endonucleases that cleave DNA. Here we review how DSBs can be repaired either by nonhomologous end-joining mechanisms or by several homologous recombination pathways including single-strand annealing, gene conversion and break-induced replication.

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Resource Type: Video, Lecture/Lecture outline
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16

Author and Copyright

Authors and Editors: Jim Haber of Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University
Publisher: iBioSeminars
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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