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Signals from Eph and Ephrin Proteins: A Developmental Tool Kit

Interactions between Eph receptor family members and their ligands, the ephrins, are critical to many important embryonic patterning events. Evidence is emerging that also implies a role in pathological processes, including cancer and tissue injury. How do 14 Eph and nine ephrin proteins generate the great complexity of signaling mechanisms required to regulate cell movements as diverse as axon guidance, tissue boundary formation, and formation of the vasculature? We review how functional complexity is generated through modular usage of Eph and ephrin components, and discuss recent observations that highlight the unusual versatility of signaling mechanisms provided by this receptor-ligand system.

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Resource Type: Bibliography, Diagram, Illustration, Image, Journal article/Issue, Review, Video
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright

Authors and Editors: Andrew W. Boyd of Leukaemia Foundation Laboratory, Queensland Institute of Medical Research, Martin Lackmann of Epithelial Biology Laboratory, Ludwig Institute for Cancer Research (Melbourne Branch)
Publisher: American Association for the Advancement of Science
Format: application/pdf, image/gif, image/jpeg, text/html, video/quicktime
Copyright and other restrictions: Yes
Cost: Yes


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