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PROTEIN DESIGN: Proteins from Scratch

Access to the article is free, however registration and sign-in are required. It is not easy to predict a protein's structure from its linear amino acid sequence, and the reverse problem--designing a protein that will assume a particular folded shape--is even harder. But on page 82 in this issue, Dahiyat and Mayo have succeeded in creating a zinc finger fold de novo, which forms the same shaped protein as the natural one but without the usual stabilizing zinc ion. In his Perspective, DeGrado explains why this problem has been so intractable and where we can go now that Dahiyat and Mayo have paved the way.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: William F. DeGrado of Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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