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CHEMISTRY: A New Route to Designer Antibiotics

Access to the article is free, however registration and sign-in are required. To overcome resistance, antibiotics must be modified regularly, but their complex structures make this a daunting task. In their Perspective, Khosla and Tang discuss how chemical synthesis and biosynthesis can complement each other in this quest for more powerful future antibiotics. They highlight the report by Charest et al., who have devised a powerful synthetic strategy for assembling novel tetracyclines, an important class of antibiotics that is widely used in humans and animals. Synthetic and biosynthetic approaches allow different parts of the tetracycline molecule to be modified with ease, and by combining the two approaches, these different strengths can be harnessed to find better antibiotics.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Chaitan Khosla of Departments of Chemistry, Stanford University, Yi Tang of Chemical Engineering, University of California
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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