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Bio-Molecular Dynamics Comes of Age

Access to the article is free, however registration and sign-in are required. Atomic force microscopy has recently been used to measure the binding force between two biomolecules; complementing the experiments are computational molecular dynamics studies that seek to reveal the details of the binding and unbinding mechanisms. In his Perspective, Berendsen discusses the results reported in the same issue by GrubmĂĽller et al. (p. 997) on numerical simulations of the binding and separation of biotin from streptavidin, which show excellent agreement with measurements of the rupture force.

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Classifications


Resource Type: Journal article/Issue, Review, Image
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright


Authors and Editors: Herman J. C. Berendsen of Department of Biophysical Chemistry and the BIOSON Research Institute, University of Groningen
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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American Association for the Advancement of Science


     
   

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