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The Tail of Integrins, Talin, and Kindlins

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in response to ligand binding; however, events within the cell can also regulate the affinity of integrins for ligands. This feature is important in physiological situations such as those in blood, in which cells are always in close proximity to their ligands, yet cell-ligand interactions occur only after integrin activation in response to specific external cues. This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-β subunits.

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Resource Type: Journal article/Issue, Diagram, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Markus Moser of Max Planck Institute of Biochemistry, Kyle Legate of Max Planck Institute of Biochemistry, Roy Zent of Vanderbilt Medical Center and Veterans Affairs Hospital, Reinhard Fässler of Max Planck Institute of Biochemistry
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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American Association for the Advancement of Science


     
   

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