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Getting Your Loops Straight

This article introduces a special issue on the study of biochemical signaling pathways. Complicated biochemical signaling pathways regulate the function of living cells. Such regulatory networks often have “downstream” components that provide input to components that act earlier in a pathway, creating feedback loops. These feedback loops have the potential to greatly alter the properties of a pathway and how it responds to stimuli. To fully understand these regulatory systems and exploit their vast potential as targets of therapeutic strategies, we need quantitative information on the flow of signals through a pathway and on the timing and location of signaling events within cells. The papers assembled in this special issue and in the companion issue of Science Signaling highlight recent progress in tackling these challenges.

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Classifications


Resource Type: Review, Journal
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: L. Bryan Ray of AAAS
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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