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Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis

The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. “Upstairs” of this event are the Bcl-2 family proteins that regulate and mediate MOMP; “downstairs” is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring “upstairs” of MOMP.

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Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Diana Spierings of La Jolla Institute for Allergy and Immunology, Gavin McStay of La Jolla Institute for Allergy and Immunology, Mayah Saleh of La Jolla Institute for Allergy and Immunology, Cheryl Bender of La Jolla Institute for Allergy and Immunology, Jerry Chipuk of La Jolla Institute for Allergy and Immunology, Uli Maurer of La Jolla Institute for Allergy and Immunology, Douglas Green of La Jolla Institute for Allergy and Immunology
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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