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Transforming Growth Factor-Ăź Signaling in Stem Cells and Cancer

This article discusses the role of transforming growth factor–β (TGF-β) and TGF-β–related proteins in stem cells. Transforming growth factor–β (TGF-β) and TGF-β–related proteins, such as the bone morphogenetic proteins, have emerged as key regulators of stem cell renewal and differentiation. These proteins have disparate roles in regulating the biology of embryonic stem cells and tumor suppression, and they help define the selection of cell fate and the progression of differentiation along a lineage. Here we illustrate their roles in embryonic stem cells and in the differentiation of neural, hematopoietic, mesenchymal, and gastrointestinal epithelial stem cells.

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Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Lopa Mishra of Cancer Genetics and Digestive Diseases, Georgetown University, Rik Derynck of Medicine & Lombardi Cancer Center, University of California, Bibhuti Mishra of Department of Veterans Affairs, Georgetown University
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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