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Linking Albinism and Immunity: The Secrets of Secretory Lysosomes

Lysosomes are membrane-bound organelles that are found in all mammalian cells and contain hydrolases and lipases required for protein and membrane degradation. In many cells of the immune system, lysosomes also contain secretory proteins that can be released by regulated exocytosis in response to an external stimulus, providing different cell types with a wide range of effector functions. Melanosomes also use a lysosome-related organelle to secrete melanin for pigmentation. Links between albinism and immunity in patients have uncovered a number of key proteins required for lysosomal secretion and have revealed a versatile secretory mechanism that can be fine-tuned by distinct interactions in different cell types.

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Resource Type: Journal article/Issue, Table, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright

Authors and Editors: Jane Stinchcombe of Sir William Dunn School of Pathology, Giovanna Bossi of Sir William Dunn School of Pathology, Gillian Griffiths of Sir William Dunn School of Pathology
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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