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Convergence of Wnt, ß-Catenin, and Cadherin Pathways

The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, β-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, β-catenin functions, and cadherin-mediated adhesion.

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Resource Type: Journal article/Issue, Diagram, Review
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: W. James Nelson of Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Roel Nusse of Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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