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Regulators of Cerebellar Granule Cell Development Act Through Specific Signaling Pathways

The proper development of the central nervous system depends upon a finely tuned balance between cell proliferation and programmed cell death (PCD). Although PCD was initially believed to depend solely on the inability of certain neurons to obtain access to a limited supply of trophic factors, it has become apparent that the local production of death signals is also critical. In this Viewpoint, we discuss several pathways implicated in the survival of cerebellar granule cells— both pathways that protect from apoptosis and pathways that promote apoptosis—and describe how these disparate pathways converge on the final common mediators of PCD. Information on other important pathways implicated in granule cell survival may be found in the Connections Maps.

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Resource Type: Journal article/Issue, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: David Vaudry of Laboratoryof Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, Anthony Falluel-Morel of Laboratoryof Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, SĂ©bastien Leuillet of Laboratoryof Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, Hubert Vaudry of Laboratoryof Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, Bruno Gonzalez of Laboratoryof Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

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Collection:
American Association for the Advancement of Science


     
   

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