HomeAbout

SIGN IN   Advanced Search










 
Browse Biotechnology
A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.


View Free
Resource

Classifications


Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Richard G. W. Anderson of Department of Cell Biology, University of Texas Southwestern Medical Center, Ken Jacobson of Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

Comments


» Sign In or register to post comments.


Collection:
American Association for the Advancement of Science


     
   

SITE MAP | CONTACT | POLICIES

Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.