HomeAbout

SIGN IN   Advanced Search










 
Browse Biotechnology
Signal Transduction by the TGF-β Superfamily

Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs function by carrying signals from the cell surface directly to the nucleus. Recent insights have revealed how SMAD proteins themselves are regulated and how appropriate subcellular localization of SMADs and TGF-β transmembrane receptors is controlled. Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.


View Free
Resource

Classifications


Resource Type: Journal article/Issue, Illustration
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate, Professional (degree program), Continuing education

Author and Copyright


Authors and Editors: Liliana Attisano of Department of Anatomy and Cell Biology, Jeffrey Wrana of Department of Medical Genetics and Microbiology, University of Toronto
Publisher: SCIENCE
Format: text/html
Copyright and other restrictions: Yes
Cost: No

Comments


» Sign In or register to post comments.


Collection:
American Association for the Advancement of Science


     
   

SITE MAP | CONTACT | POLICIES

Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.