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Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm

Signal transducers and activators of transcription (STATs) are implicated in physiological cellular processes, stress-related responses, and malignancies. This Presentation provides an overview on STATs, focusing on STAT5, and describes an in vivo biotinylation methodology applied in mammalian cells for identification of STAT5-containing protein complexes and STAT5 target genes. Our results show that in vivo biotinylation can be used efficiently to elucidate the complex STAT5-dependent transcriptional mechanisms.

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Classifications


Resource Type: Animation, Bibliography, Meeting presentation
Audience Level: Undergraduate upper division 15-16, Graduate, Professional (degree program)

Author and Copyright


Authors and Editors: Eleni Katsantoni of Biomedical Research Foundation, Academy of Athens
Publisher: American Association for the Advancement of Science
Format: application/x-shockwave-flash, text/html
Copyright and other restrictions: Yes
Cost: Yes

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STKE/Science Signaling


     
   

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