SIGN IN   Advanced Search

Browse Biotechnology
The Collaboration of Proteins During Replication

The major types of proteins, which must work together during the replication of DNA, are illustrated, showing their positions. When DNA replicates, many different proteins work together to accomplish the following steps: 1. The two parent strands are unwound with the help of DNA helicases. 2. Single stranded DNA binding proteins attach to the unwound strands, preventing them from winding back together. 3. The strands are held in position, binding easily to DNA polymerase, which catalyzes the elongation of the leading and lagging strands. (DNA polymerase also checks the accuracy of its own work!). 4. While the DNA polymerase on the leading strand can operate in a continuous fashion, RNA primer is needed repeatedly on the lagging strand to facilitate synthesis of Okazaki fragments. DNA primase, which is one of several polypeptides bound together in a group called primosomes, helps to build the primer. 5. Finally, each new Okazaki fragment is attached to the completed portion of the lagging strand in a reaction catalyzed by DNA ligase.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.

View Free


Resource Type: Diagram, Image
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14

Author and Copyright

Authors and Editors: Access Excellence, Access Excellence @ the National Health Museum
Publisher: Access Excellence @ the National Health Museum
Format: text/html
Copyright and other restrictions: Yes
Cost: No


» Sign In or register to post comments.

National Health Museum-Access Excellence



Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.