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BIOCHEMISTRY: Free Copper Ions in the Cell?

Access to the article is free, however registration and sign-in are required. How enzymes such as copper-zinc superoxide dismutase (SOD1), an important antioxidant enzyme in the cell, obtain the transition metal ions that they need to function is still far from understood. In Science this week, Rae et al. demonstrate that the yCCS metallochaperone in yeast inserts copper ions directly into the enzyme and is only active at very low concentrations of intracellular copper. Moreover, these investigators made the unexpected discovery that there is less than one atom of free copper per cell. A Perspective by Lippard comments on these findings and their implications for human diseases that involve dysregulation of transition metal ion intracellular concentrations or mutations in SOD1.

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Resource Type: Journal article/Issue, Review, Image
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Stephen J. Lippard of Department of Chemistry, Massachusetts Institute of Technology
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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