SIGN IN   Advanced Search

Browse Enzymology
MICROBIOLOGY: A Protein Pupylation Paradigm

Access to the article is free, however registration and sign-in are required.Tuberculosis, a devastating infectious disease caused by Mycobacterium tuberculosis (Mtb), is a global health threat that presently afflicts one-third of the world's population. The culprit bacterium is an obligate and persistent pathogen that maintains viability, in a latent state, within phagocytes--cells that ingest foreign materials and microorganisms--that reside in the lungs of humans. Treating tuberculosis requires prolonged antibiotic therapy that can result in multidrug-resistant Mtb strains. Because the bacterium is highly infectious, grows extremely slowly, and is difficult to manipulate genetically, the discovery of new drugs to combat Mtb infection is challenging. Thus, identifying Mtb components as potential drug targets is one of the key approaches to developing new tuberculosis therapy. Pearce et al. report the discovery of a protein (Pup) in Mtb that modifies other bacterial proteins to target them for degradation. The process is similar to that in eukaryotes, in which the protein ubiquitin modifies proteins and targets them for proteolysis. The discovery of this process in prokaryotes opens the door to further characterizing a protein regulatory mechanism that could be targeted by pathogen-specific drugs.

Rate this Resource:
1 = not useful, 5 = very useful

Please be the first to rate this resource.

View Free


Resource Type: Diagram, Journal article/Issue, Review
Audience Level: High school upper division 11-12, Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Sohini Mukherjee of Department of Immunology, University of Texas Southwestern Medical School, Kim Orth of Department of Immunology, University of Texas Southwestern Medical School
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


» Sign In or register to post comments.

American Association for the Advancement of Science



Triple A S National Science Foundation Naitonal Science Digital Library Pathway
Funded by the individual BEN Collaborators and grants from the
National Science Foundation [DUE 0085840 / DUE 0226185 / DUE 0532797 / DUE 0734995]

This website is a National Science Digital Library (NSDL) Pathway.
Copyright © 2019. American Association for the Advancement of Science. All Rights Reserved.