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SIGNAL TRANSDUCTION: Routing MAP Kinase Cascades

Access to the article is free, however registration and sign-in are required. Cells need to convey information from signals on their surface to a variety of intracellular targets, including transcription factors, contractile proteins, and enzymes. To do so efficiently, they construct information pathways with enzymes called kinases, using the same enzymes over and over. But what prevents cross talk between pathways? In her Perspective, Elion discusses new results in this issue by Whitmarsh et al. and Schaeffer et al., who identify proteins that act as scaffolds in mouse cells, binding certain kinases to make a pathway for a specific function that is insulated from the rest of the cell.

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Resource Type: Journal article/Issue, Review, Diagram
Audience Level: Undergraduate lower division 13-14, Undergraduate upper division 15-16, Graduate

Author and Copyright

Authors and Editors: Elaine A. Elion of Department of Biological Chemistry, Harvard Medical School
Publisher: AAAS
Format: text/html
Copyright and other restrictions: Yes
Cost: No


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